Ribosome Homeostasis
Upsetting the balance of ribosome supply and demand leads to disease. Mills and Green, Science 2017
Our interests in ribosome recycling and rescue have raised our interest in ribosome homeostasis and how it contributes to the regulation of gene expression. Why do ribosome deficiencies in different tissues lead to differential sensitivities to these deficiencies? How does the cell balances the demands of protein synthesis with the regulation of initiation, elongation, termination, and recycling steps of this process to ensure that gene expression happens appropriately in order to sustain the life of the organism.
