Niladri Sinha
Research Associate
Previous Institution: University of Utah
E-Mail: niladrisinha23@gmail.com
Aberrantly stalled ribosomes on messenger RNAs disrupt translational homeostasis - leading to defects in protein synthesis, and activation of downstream quality control (QC) pathways. Using biochemical, mass-spectrometric and ribosome profiling approaches, I am interested in studying how QC factors spatiotemporally recognize and resolve stalled ribosomes, and how such factors discriminate terminally (“dead end”) stalled ribosomes on defective mRNAs, from transiently paused ribosomes on elongation-limited transcripts.
